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3D printing drug film can "eliminate" cancer cells

2024-04-24 17:21

Australian scientists have developed for the first time a drug loaded 3D printed film. It is made of gel containing specific dose of anticancer drugs 5-fluorouracil and cisplatin, which can kill cancer cells, significantly reduce the recurrence rate, and minimize the toxicity of traditional chemotherapy. The relevant research papers were published in the latest issue of the International Journal of Pharmacy.

More than 800000 people worldwide are diagnosed with liver cancer every year. The current main treatment plan is surgical resection of the tumor, followed by chemotherapy. Although this is crucial for preventing recurrence, it can bring side effects, and many patients choose to stop treatment.

In view of this, researchers have developed a new type of postoperative chemotherapy loaded film that can directly release 5-fluorouracil and cisplatin to the surgical site. The results showed that it can kill potential residual cancer cells and reduce the side effects of traditional chemotherapy. This film was initially developed as an adjuvant therapy for liver cancer, but it can also be used to treat other cancers such as ovarian cancer and head and neck cancer.

In addition, the film can control drug release for up to 23 days, ensuring sustained therapeutic effects.

Researchers say that using the most advanced 3D printing technology, they can tailor treatment plans for each patient, including customizing the geometry of the film, adjusting the drug release curve, and adding or removing active ingredients. In addition, the film also has biodegradable properties.

The research team plans to conduct preclinical trials on the film to further clarify the correlation between tumor size and optimal administration and dosage, laying the foundation for future clinical trials.